Complete Moira's Wasteland Survival Guide tasks in Megaton early. Always go for the optional objectives to get the best rewards.
Take Educated . It grants extra skill points every single time you level up. fallout-3-game-of-the-year-edition
Defuse the bomb rather than blowing it up. Saving Megaton gives you access to a safe home, merchants, and a central quest hub. Complete Moira's Wasteland Survival Guide tasks in Megaton
Leave room for the stat-boosting Bobbleheads scattered across the Capital Wasteland. It grants extra skill points every single time you level up
Use duplicate weapons and armor in your inventory to repair the ones you have equipped. It saves inventory weight and increases weapon damage. 🚀 Tackling the DLCs Guide :: The (almost) Perfect Start to a New Game
Never drink or sell Nuka-Cola or Nuka-Cola Quantum. Save them for the Nuka-Cola Challenge quest later.
Start with 9 Intelligence. This maximizes your skill points per level up right from the beginning.