[s5e22] What A Difference A Day Makes | RECENT — 2025 |

The episode's central plot twist occurs when Meredith and Derek decide to give their meticulously planned wedding to Izzie and Alex.

: As a wedding gift, Derek gives Meredith her first solo surgery—a successful colon surgery overseen by Richard Webber.

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately. [S5E22] What a Difference a Day Makes

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. The episode's central plot twist occurs when Meredith

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation.

: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness. : Jeffrey Dean Morgan makes a final appearance

: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party.