The narrative progresses through over 30 main missions, including:
: The story follows four roommates who are struggling to pay off their student loans and survive in a city ruled by lawless factions. The narrative progresses through over 30 main missions,
: Establishing the Saints' headquarters in an abandoned church. The narrative progresses through over 30 main missions,
: The Boss's chaotic first day at Marshall. The narrative progresses through over 30 main missions,
: The final confrontation to solidify the Saints' control over Santo Ileso.