: Joan Cusack's character leaves the series after her house explodes, marking her exit from the show.
: Frank forms a rare, genuine emotional bond with a terminally ill doctor named Bianca, acting as her guide through reckless experiences before her death. Shameless Season 5
Ian is hospitalized; Fiona faces the fallout of Jimmy's return " Drugs Actually " Christopher Chulack : Joan Cusack's character leaves the series after
: The season ends with Mickey being incarcerated after a shootout with Sammi. Shameless Season 5
: Lip tries to balance his South Side roots with his life at university, which includes a complicated relationship with a professor.