In Season 1, Episode 3 of , titled " Ghosts of Illyria ," the crew of the Enterprise faces a biological crisis that uncovers a deeply guarded secret belonging to Number One (Una Chin-Riley). The Story of "Ghosts of Illyria"
: After the crew is cured and the Enterprise is safe, Una confesses her true identity to Captain Pike, expecting to be court-martialed or discharged. However, Pike, valuing her character and bravery over rigid regulations, refuses her resignation and chooses to keep her secret. Star Trek Strange New Worlds s01e03
: On the Enterprise , Number One appears to be the only one immune to the infection. It is revealed that she is an Illyrian , a species known for genetic engineering, which is strictly forbidden in the United Federation of Planets. Her immune system’s "glow-worm" antibodies are actually fighting off the virus, and she eventually uses her own blood to synthesize a cure for the rest of the crew. In Season 1, Episode 3 of , titled