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Tg2 -
When things go wrong, TG2 shifts roles. In the extracellular space, it binds to integrins and acts as a co-receptor, facilitating cell adhesion and migration.
Inside the cell, TG2 contributes to survival pathways. However, its dysregulation is linked to celiac disease, fibrosis, and tumor progression, making it a critical player in disease research. When things go wrong, TG2 shifts roles
#CellBiology #MolecularBiology #CancerResearch #TG2 #SciencePost #ProteinStudies If this was not the "TG2" you were looking for, please 3D rendering software. However, its dysregulation is linked to celiac disease,
I can tailor the content to the specific, actionable information you need! TG2 acts as a "molecular glue," crosslinking extracellular
TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing.
Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats:
Because TG2 is implicated in chronic conditions like cancer and neurodegeneration (such as Huntington's and Alzheimer's), it is now a hot target for new therapeutic drugs designed to selectively inhibit its activity without harming healthy cells.
