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Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding.

Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power tm,cc,jp

Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power

It tethers vesicles to the plasma membrane, facilitating sound encoding. Based on the 2025 research regarding the protein

The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").

This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs. Key Findings in Synaptic Transmission Ca 2+raised to

The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.